Calcipotriol

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[edit] BRAND NAMES

[edit] STRUCTURE

Calcipotriol.jpg

[edit] MECHANISM OF ACTION

Calcipotriol is a Vitamin D derivative. In vitro data suggest that calcipotriol induces differentiation and supresses proliferation of keratinocytes. This is the proposed basis for its effect in psoriasis.

[edit] INDICATIONS

Treatment of mild to moderate plaque psoriasis

[edit] DOSAGE

0.005% cream or ointment: Apply a thin layer to the affected skin twice daily and rub in gently and completely

[edit] CONTRAINDICATIONS

  • History of hypersensitivity to any of the components.
  • Patients with demonstrated hypercalcemia or evidence of vitamin D toxicity.
  • Calcipotriol cream/ointment should not be used on the face. An itchy red rash may develop

[edit] WARNINGS AND PRECAUTIONS

  • Calcipotriol cream may cause transient irritation of both lesions and surrounding uninvolved skin. If irritation develops calcipotriol cream should be discontinued.
  • Reversible elevation of serum calcium has occurred with use of topical calcipotriene. If elevation in serum calcium outside the normal range should occur, discontinue treatment until normal calcium levels are restored.
  • Protect the treated skin areas from sunlight and Ultra Violet (UV) rays, for example, by wearing protective clothing.

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

  • Pregnancy Category C (US). Calcipotriol cream should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
  • Nursing mothers: It is not known whether calcipotriol is excreted in breast milk. Calcipotriol should not be used during lactation unless clearly necessary.

[edit] SIDE EFFECTS

The most frequently reported undesirable effects are various skin reactions like pruritus, skin irritation, burning and stinging sensation, dry skin, erythema and rash .

Contact dermatitis, eczema and worsening of psoriasis are uncommon.

Systemic effects after topical use: Hypercalcemia or hypercalciuria have been reported very rarely.

Transient changes in skin pigmentation, transient photosensitivity reactions and hypersensitivity reactions including urticaria, angioedema, periorbital or face edema have been reported very rarely.

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