Brivudine

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[edit] BRAND NAMES

[edit] STRUCTURE

Brivudine.jpg

[edit] MECHANISM OF ACTION

Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication.

The active compound is the 5'-triphosphate of Brivudine, which is formed in subsequent phosphorylations by viral thymidine kinase and presumably by nucleoside diphosphate kinase.

[edit] INDICATIONS

Treatment of herpes zoster.

[edit] DOSAGE

Tablets: 125 mg once daily X 7 days. A single daily dose of 125 mg is found to be effective, compared with acyclovir 800 mg five times a day or famciclovir 250 mg three times a day, all given orally.

[edit] CONTRAINDICATIONS

[edit] PRECAUTIONS

[edit] INTERACTIONS

Brivudine inhibits the breakdown of 5-fluoropyrimidines such as 5-fluorouracil and 5-FU prodrugs such as capecitabine (Xeloda), floxuridine and tegafur. It can therefore lead to a potentially fatal accumulation of 5-FU. Simultaneous use of brivudine even with topical 5-fluoropyrimidine products is absolutely contraindicated. An interval of at least four weeks should elapse between treatment with brivudine, and subsequent administration of 5-fluoropyrimidine products.

[edit] PREGNANCY AND LACTATION

[edit] SIDE EFFECTS

The most common side effect is nausea.

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES