BRAND NAMES
- Difflam, Tantum, Tantum Verde, Vantal (lozenges, throat spray, oral solution)
- Rosalgin, Tantum Rosa (vaginal solution)
 MECHANISM OF ACTION
Benzydamine is a non-steroidal anti-inflammatory drug (NSAID). Benzydamine inhibits the enzyme, cyclooxygenase (COX), an early component of the arachidonic acid cascade, resulting in the reduced formation of prostaglandins. Prostaglandins act as messenger molecules in the process of inflammation.
Benzydamine is therefore effective at reducing inflammation and pain. It also acts as a local anaesthetic, causing numbness and so pain relief at the site of application.
- To treat painful mouth or throat conditions, such as mouth ulcers and sores, sore throat, pain and inflammation following dental surgery
- Vulvovaginitis and exocervicitis of any origin and nature, pre- and post-operation prophylaxis in gynaecological surgery, and female hygiene during puerpery.
- Lozenges, Adults and children over 6 years old: The usual dose is: one lozenge 3 times a day, for not more than 7 days.
- Oral solution: Rinse or gargle with 15 ml (about 1 tablespoonful) every 1.5 to 3 hours as required to relieve pain. After gargling, spit out the rinse and do not swallow it.
- Vaginal use: 1-2 vaginal irrigations per day. Gently introduce the cannula in the vagina and squeeze the vial until it becomes empty. When possible, perform the irrigation in the lying down position. To fully benefit from the therapeutic activity, keep the liquid inside the vagina for a few minutes.
- hypersensitivity to the active substance or any of its excipients.
- Benzydamine is not recommended in allergic patients to acetylsalicylic acid or to other anti-inflammatory painkillers called NSAIDs.
 PREGNANCY AND LACTATION
- Vaginal solution: The toxicological and clinical studies performed with Benzidamina have demonstrated that Benzydamine (Vaginal solution) is free of toxic effects in the recommended doses; nevertheless, a close monitoring is advised.
 SIDE EFFECTS
- Uncommon side effects (between 1 and 10 in every 1,000 people are likely to get these):
- Skin sensitivity to sunlight (causing a rash or sunburn).
- Rare side effects (between 1 and 10 in every 10,000 people are likely to get these):
- Burning sensation or dryness of the mouth. If this happens to you, try sipping a glass of water to reduce the effect.
- Allergic reaction, rash or itching especially if affecting the whole body (hypersensitivity reaction).
- Very rare side effects (less than 1 in every 10,000 people are likely to get these):
- sudden swelling in the mouth/throat and mucous membranes (angioedema).
- difficulty breathing (laryngospasm).
- Not known (cannot be estimated from the available data):
- severe allergic reactions (anaphylactic reactions)
 RELATED LINKS
|Non-steroidal anti-inflammatory drugs (NSAIDs)|
|Non-selective (COX-1 and COX-2 inhibitors)||Aceclofenac • Acetylsalicylic acid • Benzydamine • Diclofenac • Flurbiprofen • Ibuprofen • Indometacin • Ketoprofen • Ketorolac • Ketorolac • Lornoxicam • Mefenamic acid • Morniflumate • Nabumetone • Naproxen • Niflumic acid • Piroxicam • Tenoxicam|
|Relatively COX-2 selective||Meloxicam • Nimesulide|
|COX-2 selective inhibitors (Coxibs)||Celecoxib • Etoricoxib • Parecoxib|
|Ophthalmic NSAIDs||Bromfenac (ophthalmic) • Diclofenac (ophthalmic) • Flurbiprofen (ophthalmic) • Ketorolac (ophthalmic) • Nepafenac (ophthalmic)|
|Veterinary use||Carprofen • Deracoxib • Firocoxib • Mavacoxib • Robenacoxib|