BRAND NAMES
 MECHANISM OF ACTION
Benzonatate, a non-narcotic antitussive agent chemically related to tetracaine and other ester-type local anesthetics, it acts peripherally by anesthetizing the stretch receptors of vagal afferent fibers in the alveoli of the lungs, bronchi, and pleura by dampening their activity and thereby reducing the cough reflex at its source. It begins to act within 15 to 20 minutes and its effect lasts for 3 to 8 hours.
Symptomatic relief of cough associated with both acute and chronic respiratory conditions.
Adults and Children over 10 years of age: swallow a 100 mg or 200 mg capsule three times a day
Hypersensitivity to benzonatate
 WARNINGS AND PRECAUTIONS
- Severe hypersensitivity reactions (including bronchospasm, laryngospasm and cardiovascular collapse) have been reported which are possibly related to local anesthesia from sucking or chewing the capsule instead of swallowing it. Severe reactions have required intervention with vasopressor agents and supportive measures.
- Isolated instances of bizarre behavior, including mental confusion and visual hallucinations, have also been reported in patients taking benzonatate in combination with other prescribed drugs.
- Benzonatate is chemically related to anesthetic agents of the para-amino-benzoic acid class (e.g., procaine; tetracaine) and has been associated with adverse CNS effects possibly related to a prior sensitivity to related agents or interaction with concomitant medication.
 PREGNANCY AND LACTATION
- Pregnancy Category C (US). It is also not known whether benzonatate can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Benzonatate should be given to a pregnant woman only if clearly needed.
- Nursing mothers: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk caution should be exercised when benzonatate is administered to a nursing woman
 SIDE EFFECTS
Potential Adverse Reactions to benzonatate may include:
- Hypersensitivity reactions including bronchospasm, laryngospasm, cardiovascular collapse possibly related to local anesthesia from chewing or sucking the capsule.
- CNS: sedation; headache; dizziness; mental confusion; visual hallucinations.
- GI: constipation, nausea, GI upset.
- Dermatologic: pruritus; skin eruptions.
- Other: nasal congestion; sensation of burning in the eyes; vague "chilly" sensation; numbness of the chest; hypersensitivity.
- Rare instances of deliberate or accidental overdose have resulted in death.
 RELATED LINKS
|Antitussives / Cough|
|Cough suppressants||Benzonatate • Butamirate • Codeine • Dextromethorphan • Dihydrocodeine • Dropropizine • Levocloperastine • Levodropropizine • Nepinalone • Oxolamine|
|Mucolytics||Acetylcysteine • Ambroxol (Oral) • Bromhexine • Carbocisteine • Erdosteine • Guaifenesin • Neltenexine|