Erythromycin/Benzoyl peroxide

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Erythromycin is a macrolide antibiotic produced by Streptomyces erythraeus. it binds to the 50S ribosomal subunit, inhibiting bacterial protein synthesis.
Erythromycin penetrates into the ducts of the sebaceous glands of the skin and unflods its specific effect at this site against bacterias which are involved in the development of acne.

Benzoyl peroxide is an antibacterial agent which has been shown to be effective against Propionibacterium acnes. This action is believed to be responsible for its usefulness in acne.
Benzoyl peroxide, exerts also a desquamative action and provides mild peeling and keratolytic activity.


Topical treatment of acne vulgaris

[edit] DOSAGE

Erythromycin/Benzoyl peroxide topical gel should be applied twice daily, morning and evening, or as directed by a physician, to affected areas after the skin is thoroughly washed, rinsed with warm water and gently patted dry.


  • Hypersensitivity to Erythromycin or to Benzoyl peroxide


  • Pseudomembranous colitis has been reported with nearly all antibacterial agents, including erythromycin, and may range in severity from mild to life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents.
    Treatment with antibacterial agents alters the normal flora of the colon and may permit overgrowth of clostridia. Studies indicate that a toxin produced by Clostridium difficile is one primary cause of "antibiotic-associated colitis."
    After the diagnosis of pseudomembranous colitis has been established, therapeutic measures should be initiated. Mild cases of pseudomembranous colitis usually respond to drug discontinuation alone. In moderate to severe cases, consideration should be given to management with fluids and electrolytes, protein supplementation and treatment with an antibacterial drug clinically effective against C. difficile colitis.
  • Concomitant topical acne therapy should be used with caution because a possible cumulative irritancy effect may occur, especially with the use of peeling, desquamating or abrasive agents. If severe irritation develops, discontinue use and institute appropriate therapy.
  • The use of antibiotic agents may be associated with the overgrowth of nonsusceptible organisms including fungi. If this occurs, discontinue use and take appropriate measures.
  • Avoid contact with eyes and all mucous membranes.


  • Pregnancy Category C (US). There are no well-controlled trials in pregnant women with Erythromycin/Benzoyl peroxide Topical Gel. It also is not known whether Erythromycin/Benzoyl peroxide Topical Gel can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. Erythromycin/Benzoyl peroxide Topical Gel should be given to a pregnant woman only if clearly needed.
  • Nursing Women: It is not known whether Erythromycin/Benzoyl peroxide Topical Gel is excreted in human milk after topical application. However, erythromycin is excreted in human milk following oral and parenteral erythromycin administration. Therefore, caution should be exercised when erythromycin is administered to a nursing woman.


In controlled clinical trials, the incidence of adverse reactions associated with the use of Erythromycin/Benzoyl peroxide Topical Gel was approximately 3%. These were dryness and urticarial reaction.

The following additional local adverse reactions have been reported occasionally: irritation of the skin including peeling, itching, burning sensation, erythema, inflammation of the face, eyes and nose, and irritation of the eyes. Skin discoloration, oiliness and tenderness of the skin have also been reported.


Acne Treatments



Oral antibiotics Clindamycin (Oral route)   Doxycycline   Erythromycin (Oral route)   Josamycin   Lymecycline   Minocycline   Tetracycline
Topical antibiotics Clindamycin (Topical)   Erythromycin (Topical)
Topical retinoids Adapalene   Tazarotene   Tretinoin
Oral retinoids Isotretinoin (Oral)
Oral contraceptives Estradiol valerate/Dienogest   Ethinyl Estradiol/Cyproterone acetate
Topical Antibacterial/Keratolytic Benzoyl peroxide   Hydrogen Peroxide Cream
Topical combination products Clindamycin/Benzoyl peroxide   Adapalene/Benzoyl peroxide   Clindamycin/Tretinoin   Miconazole/Benzoyl peroxide   Erythromycin/Benzoyl peroxide   Erythromycin/Isotretinoin