Lorcaserin

From Drugs Prescribing Information
(Redirected from Belviq)
Jump to: navigation, search
Click on "►" to expand:

Contents

[edit] BRAND NAMES

[edit] STRUCTURE

File:Lorcaserin.jpg

[edit] MECHANISM OF ACTION

Lorcaserin is believed to decrease food consumption and promote satiety by selectively activating 5-HT2C receptors on anorexigenic proopiomelanocortin neurons located in the hypothalamus. The exact mechanism of action is not known.

[edit] INDICATIONS

Lorcaserin is indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of:

  • 30 kg/m2 or greater (obese)
  • 27 kg/m2 or greater (overweight) in the presence of at least one weight related comorbid condition, (e.g., hypertension, dyslipidemia, type 2 diabetes)

Limitations of Use:

  • The safety and efficacy of coadministration with other products for weight loss have not been established
  • The effect of BELVIQ on cardiovascular morbidity and mortality has not been established

[edit] DOSAGE

One tablet of 10 mg twice daily. Discontinue if 5% weight loss is not achieved by week 12.

[edit] DOSAGE FORMS AND STRENGTHS

  • 10 mg film-coated tablets

[edit] CONTRAINDICATIONS

  • Pregnancy

[edit] WARNINGS AND PRECAUTIONS

  • Serotonin Syndrome or Neuroleptic Malignant Syndrome (NMS)-like Reactions: The safety of coadministration with other serotonergic or antidopaminergic agents has not been established. Manage with immediate Lorcaserin discontinuation and provide supportive treatment.
  • Valvular heart disease: If signs or symptoms develop consider Lorcaserin discontinuation and evaluate the patient for possible valvulopathy.
  • Cognitive Impairment: May cause disturbances in attention or memory. Caution with use of hazardous machinery when starting Lorcaserin treatment.
  • Psychiatric Disorders, including euphoria and dissociation: Do not exceed recommended dose of 10 mg twice daily.
  • Monitor for depression or suicidal thoughts. Discontinue if symptoms develop.
  • Use of Antidiabetic Medications: weight loss may cause hypoglycemia. Monitor blood glucose. Lorcaserin has not been studied in patients taking insulin.
  • Priapism: Patients should seek emergency treatment if an erection lasts >4 hours. Use Lorcaserin with caution in patients predisposed to priapism.

[edit] INTERACTIONS

Serotonergic drugs (selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), monoamine oxidase inhibitors (MAOIs), triptans, bupropion, dextromethorphan, St. John’s Wort): use with extreme caution due to the risk of serotonin syndrome

[edit] PREGNANCY AND LACTATION

[edit] SIDE EFFECTS

Most common adverse reactions (greater than 5%) in non-diabetic patients are headache, dizziness, fatigue, nausea, dry mouth, and constipation, and in diabetic patients are hypoglycemia, headache, back pain, cough, and fatigue

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES