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 BRAND NAMES
 MECHANISM OF ACTION
Lorcaserin is believed to decrease food consumption and promote satiety by selectively activating 5-HT2C receptors on anorexigenic proopiomelanocortin neurons located in the hypothalamus. The exact mechanism of action is not known.
Lorcaserin is indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of:
- 30 kg/m2 or greater (obese)
- 27 kg/m2 or greater (overweight) in the presence of at least one weight related comorbid condition, (e.g., hypertension, dyslipidemia, type 2 diabetes)
Limitations of Use:
- The safety and efficacy of coadministration with other products for weight loss have not been established
- The effect of BELVIQ on cardiovascular morbidity and mortality has not been established
One tablet of 10 mg twice daily. Discontinue if 5% weight loss is not achieved by week 12.
 DOSAGE FORMS AND STRENGTHS
- 10 mg film-coated tablets
 WARNINGS AND PRECAUTIONS
- Serotonin Syndrome or Neuroleptic Malignant Syndrome (NMS)-like Reactions: The safety of coadministration with other serotonergic or antidopaminergic agents has not been established. Manage with immediate Lorcaserin discontinuation and provide supportive treatment.
- Valvular heart disease: If signs or symptoms develop consider Lorcaserin discontinuation and evaluate the patient for possible valvulopathy.
- Cognitive Impairment: May cause disturbances in attention or memory. Caution with use of hazardous machinery when starting Lorcaserin treatment.
- Psychiatric Disorders, including euphoria and dissociation: Do not exceed recommended dose of 10 mg twice daily.
- Monitor for depression or suicidal thoughts. Discontinue if symptoms develop.
- Use of Antidiabetic Medications: weight loss may cause hypoglycemia. Monitor blood glucose. Lorcaserin has not been studied in patients taking insulin.
- Priapism: Patients should seek emergency treatment if an erection lasts >4 hours. Use Lorcaserin with caution in patients predisposed to priapism.
Serotonergic drugs (selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), monoamine oxidase inhibitors (MAOIs), triptans, bupropion, dextromethorphan, St. John’s Wort): use with extreme caution due to the risk of serotonin syndrome
 PREGNANCY AND LACTATION
- Pregnancy Category X (US)
- Nursing Mothers: Discontinue drug or nursing
 SIDE EFFECTS
Most common adverse reactions (greater than 5%) in non-diabetic patients are headache, dizziness, fatigue, nausea, dry mouth, and constipation, and in diabetic patients are hypoglycemia, headache, back pain, cough, and fatigue