Beclomethasone (Nasal spray)
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 BRAND NAMES
- Canada: Apo-Beclomethasone
- Italy: Becotide, Inalone, Rinoclenil, Turbinal
- UK: Beconase
- US: Beconase PI
 MECHANISM OF ACTION
Beclomethasone dipropionate, a synthetic halogenated glucocorticoid is a pro-drug with weak glucocorticoid receptor binding affinity. It is hydrolyzed via esterase enzymes to its active metabolite beclomethasone-17-monopropionate (B-17-MP), which has high antiinflammatory and vasoconstrictive activity.
Glucocorticoids cross cell membranes and bind with high affinity to specific cytoplasmic receptors. The result includes inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of corticosteroids involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
- Relief of the symptoms of seasonal or perennial allergic and nonallergic (vasomotor) rhinitis in adults and children six years of age and older.
- Prevention of recurrence of nasal polyps following surgical removal.
Shake the suspension spray bottle well before using it.
- Adults and children 12 years of age and older: The usual dose is 50-100 mcg into each nostril morning and evening.
- Children 6-12 years of age: 50 mcg in each nostril, morning and evening.
Significant symptomatic relief can occur within 3 days of initiating the treatment, but it may take 2 weeks to achieve maximum benefit.
- Hypersensitivity to any of the ingredients of the preparation
- Intranasal corticosteroids may cause a reduction in growth velocity when administered to pediatric patients
- Beclomethasone Nasal spray has an inhibitory effect on nasal wound healing. Do not use it until healing has occurred.
 PREGNANCY AND LACTATION
- Pregnancy Category C (US). Beclomethasone Spray should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
- Nursing Mothers: It is not known whether Beclomethasone is excreted in human milk. Caution should be exercised if administered to nursing women.
 SIDE EFFECTS
Adverse events include: Sneezing after spraying or irritated nose, nose bleeding, rhinorrhea, tearing eyes, dizziness and headache.
Rare adverse events include: nasal septum perforation, pharynx disorders (throat irritation, throat pain, swollen throat, burning throat, and itchy throat), wheezing, cataracts, glaucoma, and increased intraocular pressure, angioedema and development of localized infections of the nose and pharynx with Candida albicans.