Beclomethasone (Inhaler)

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[edit] BRAND NAMES

[edit] STRUCTURE

Beclometasone

[edit] MECHANISM OF ACTION

Beclometasone is an inhaled glucocorticoid, it works in the air passages of the lungs by reducing inflammation and keeping the airways open, making it easier to breathe.

Glucocorticoids have multiple antiinflammatory effects, inhibiting both inflammatory cells and release of inflammatory mediators.

[edit] INDICATIONS

  • To prevent shortness of breath or asthma as a maintenance treatment in patients 5 years of age and older.
  • Beclomethasone (Inhaler) is also indicated for asthma patients who require systemic corticosteroid administration, where adding it may reduce or eliminate the need for the systemic corticosteroids.

Beclomethasone (Inhaler) won't give a fast relief once an acute bronchospasm attack has started.

[edit] DOSAGE

  • Adults: 80 to 400 micrograms a day, divided in two doses. Max 800 micrograms a day, divided in two doses. [1]
  • Children 5 to 11 Years: 80 micrograms a day, divided in two doses. Max 160 micrograms a day, divided in two doses.

[edit] CONTRAINDICATIONS

  • Acute bronchospasm attack requiring intensive measures

[edit] WARNINGS AND PRECAUTIONS

  • Candida albicans infection of the mouth and pharynx. Monitor patients periodically for signs of adverse effects in the mouth and pharynx. Advise patients to rinse mouth after inhalation
  • Beclomethasone (Inhaler) should not be used for relief of acute bronchospasm attacks
  • Hypersensitivity reactions including anaphylaxis, angioedema, pruritus, and rash have been reported rarely. Discontinue Beclomethasone (Inhaler) if such reactions occur.
  • Potential worsening of existing tuberculosis; fungal, bacterial, viral, or parasitic infection; or ocular herpes simplex, chickenpox or measles. Use caution in patients with the above because of the potential for worsening of these infections
  • Decreases in bone mineral density (BMD) have been observed with long-term administration of products containing inhaled corticosteroids
  • Glaucoma, increased intraocular pressure, and cataracts have been reported following the long-term administration of inhaled corticosteroids.
  • Orally inhaled corticosteroids may cause a reduction in growth velocity when administered to pediatric patients. Monitor the growth of pediatric patients
  • Paradoxical bronchospasm may occur with Beclomethasone (Inhaler). Treat bronchospasm immediately with a fast-acting inhaled bronchodilator (Salbutamol) and discontinue use of Beclomethasone (Inhaler).

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

  • Pregnancy Category C (US), There are no adequate and well controlled studies in pregnant women. Beclomethasone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
  • Beclometasone is secreted in human milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue Beclometasone inhaler.

[edit] SIDE EFFECTS

May cause infection of the mouth and throat (rinsing your mouth and gargling with water after using the inhaler may avoid such inconvenience, headache, hoarse voice, dry irritated throat, cough and dysmenorrhea.

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES

  1. http://www.dottnet.it/TFI/Allegati.aspx?file=2011-11-001060-Clenilexx.pdf
Asthma / Chronic obstructive pulmonary disease (COPD)
Adrenergics, inhalants Short acting β2-agonists Fenoterol (Berotec)   Levosalbutamol (Xopenex)   Salbutamol (Ventolin)   Terbutaline (Bricanyl)
Long acting β2-agonists (LABA) Arformoterol (Brovana)   Clenbuterol (Spiropent)   Formoterol (Foradil)   Salmeterol (Serevent)
Ultra long acting β2-agonists Indacaterol   Olodaterol   Vilanterol
Inhaled corticosteroids Beclomethasone (Inhaler)   Budesonide (Inhaler)   Ciclesonide (Inhaler)   Flunisolide (Inhalation suspension)   Fluticasone (Inhaler)   Mometasone (Inhaler)
Anticholinergics (Muscarinic antagonists) Aclidinium bromide   Glycopyrronium bromide   Ipratropium bromide   Oxitropium bromide (Inhalation suspension)   Tiotropium bromide
Mast cell stabilizers Cromoglicate   Nedocromil
Monoclonal anti-IgE antibody Omalizumab
Xanthine derivatives Aminophylline   Bamifylline   Doxofylline   Dyphylline   Theophylline
Eicosanoid inhibition Leukotriene antagonists Montelukast   Pranlukast   Zafirlukast
Thromboxane receptor antagonists Ramatroban   Seratrodast
Non-xanthine PDE4 inhibitors Ibudilast   Roflumilast
Combination products Corticosteroid + Long acting Beta2 agonist Beclomethasone/Formoterol (Inhaler)   Fluticasone/Salmeterol (Inhaler)   Fluticasone/Vilanterol   Mometasone/Formoterol
Corticosteroid + Short acting Beta2 agonist Beclomethasone/Salbutamol   Salbutamol/Flunisolide (Inhalation suspension)   Salbutamol/Flunisolide (Inhaler)
Short acting Beta2 agonist + Muscarinic antagonist Fenoterol/Ipratropium bromide (Inhaler)   Levosalbutamol/Ipratropium   Salbutamol/Ipratropium bromide