Azelastine (Nasal spray)

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[edit] BRAND NAMES

[edit] STRUCTURE

Azelastine.jpg

[edit] MECHANISM OF ACTION

Azelastine is a potent, second-generation, selective, histamine H1-receptor antagonist. Its major metabolite, desmethylazelastine, also possesses H1-receptor antagonist activity.

[edit] INDICATIONS

Azelastine (Nasal spray) is indicated for the relief of the symptoms of seasonal and perennial allergic rhinitis like runny nose, sneezing, itching or blocked nose

[edit] DOSAGE

1-2 sprays per nostril, once or twice daily

[edit] CONTRAINDICATIONS

  • Known hypersensitivity to azelastine

[edit] WARNINGS AND PRECAUTIONS

  • Somnolence may occur. Avoid engaging in hazardous occupations requiring complete mental alertness such as driving or operating machinery when taking Azelastine Nasal Spray
  • Avoid concurrent use of alcohol or other central nervous system (CNS) depressants, because further decreased alertness and impairment of CNS performance may occur

[edit] PREGNANCY AND LACTATION

  • Pregnancy Category C (US): Azelastine Nasal Spray should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
  • Nursing Mothers: It is not known whether azelastine is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Azelastine Nasal Spray is administered to a nursing woman

[edit] SIDE EFFECTS

The most common adverse reactions (≥2% incidence) are: bitter taste, nasal discomfort, epistaxis, headache, sneezing, fatigue, somnolence, and upper respiratory infection

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES