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[−] Acne treatments
 BRAND NAMES
 MECHANISM OF ACTION
Azelaic acid is effective in the treatment of acne because it possesses antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis. The antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis. A normalization of keratinization leading to an anticomedonal effect of azelaic acid may also contribute to its clinical activity.
Azelaic acid acts also as an anti-inflammatory agent in both acne and rosacea.
As a tyrosinase inhibitor, azelaic acid reduces synthesis of melanin and can been used for treatment of skin pigmentation including melasma and post-inflammatory hyperpigmentation in acne
- Topical treatment of mild-to-moderate inflammatory acne vulgaris.
- Topical treatment of inflammatory papules and pustules of mild to moderate rosacea.
- Azelaic acid is also an effective and well-tolerated treatment for hyperpigmentation in darker-skinned 
Apply to the affected areas twice daily, in the morning and evening. The duration of use can vary from person to person and depends on the severity of the acne
- Hypersensitivity to Azelaic acid
- A Temporary skin irritation (pruritus, burning, or stinging) may occur when this drug is applied to broken or inflamed skin, usually at the start of treatment. However, this irritation commonly subsides if treatment is continued. If it continues, Azelaic acid should be applied only once-a-day, or the treatment should be discontinued
- There have been isolated reports of hypopigmentation after use of azelaic acid.
- Azelaic acid has been reported to cause irritation of the eyes. Therefore, avoid contact with the eyes and mucous membranes
 PREGNANCY AND LACTATION
- Pregnancy Category B (US) Azelaic acid should be used during pregnancy only if clearly needed.
- Nursing Mothers: caution should be exercised when Azelaic acid is administered to a nursing mother
 SIDE EFFECTS
The most common adverse reactions are burning/stinging/tingling , pruritus, scaling/dry skin/xerosis, and erythema/irritation.
The following additional adverse experiences have been reported rarely: worsening of asthma, vitiligo depigmentation, small depigmented spots, hypertrichosis (abnormal amount of hair growth), reddening (signs of keratosis pilaris), and exacerbation of recurrent herpes labialis.