Azelastine (Eye drops)

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[edit] BRAND NAMES

[edit] STRUCTURE

Azelastine.jpg

[edit] MECHANISM OF ACTION

Azelastine Eye drops controls the itch of allergy eyes, thanks to its unique triple-action:

  • Histamine H1-receptor antagonist: Quickly relieves the itching that hits you minutes after an allergen enters your eye and the allergic reaction starts.2
  • Mast cell stabilization: Works on certain cells in the eye to prevent flare-ups in the short term.
  • Inflammatory cell and mediator inhibition: Provides long-term relief by inhibiting cells that prolong the allergic reaction.

[edit] INDICATIONS

Azelastine (Eye drops) is used to treat itching eyes caused by allergies (allergic conjunctivitis).

[edit] DOSAGE

The recommended dose is one drop instilled into each affected eye twice a day Azelastine (Eye drops) give fast and effective relief of itchy eyes within 3 minutes. The relief lasts for 8-10 hours.

[edit] CONTRAINDICATIONS

  • Known hypersensitivity to azelastine or to any other component.

[edit] WARNINGS AND PRECAUTIONS

  • Remove contact lenses before using this medication because it contains a preservative (Benzalkonium chloride) that can be absorbed by them. Wait at least 10 minutes after using this medication before putting the lenses back in. Do not wear contact lenses if your eyes are red.

[edit] PREGNANCY AND LACTATION

  • Pregnancy Category C (US): Azelastine (Eye drops) should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
  • Nursing Mothers: It is not known whether azelastine is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Azelastine is administered to a nursing woman

[edit] SIDE EFFECTS

the most frequently reported adverse reactions were transient eye burning/stinging (approximately 30%), headaches (approximately 15%) and bitter taste (approximately 10%). The occurrence of these events was generally mild.

The following events were reported in 1–10% of patients: asthma, conjunctivitis, dyspnea, eye pain, fatigue, influenza-like symptoms, pharyngitis, pruritus, rhinitis and temporary blurring. Some of these events were similar to the underlying disease being studied.

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