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 BRAND NAMES
- India: Optithrocin (1% ointment)
- Italy: Azyter
- U.S.: Azasite prescribing information, Patient information
 MECHANISM OF ACTION
Azithromycin is a macrolide antibiotic, it binds to the 50 S subunit of bacterial ribosomes, inhibiting protein synthesis in bacterial cells.
Azithromycin (Ophthalmic) is indicated for the treatment of bacterial conjunctivitis caused by susceptible isolates of the following microorganisms: CDC coryneform group G, Haemophilus influenzae, Staphylococcus aureus, Streptococcus mitis group, and Streptococcus pneumoniae.
1% or 1,5% (15 mg/g) sterile topical ophthalmic solution: Instill 1 drop in the affected eye(s) twice daily, eight to twelve hours apart for the first two days and then instill 1 drop in the affected eye(s) once daily for the next five days
Hypersensitivity to any component of the product.
 WARNINGS AND PRECAUTIONS
- Growth of resistant organisms may occur with prolonged use.
- Patients should not wear contact lenses if they have signs or symptoms of bacterial conjunctivitis.
 PREGNANCY AND LACTATION
Pregnancy Category B (US). Reproduction studies have been performed in rats and mice at doses up to 200 mg/kg/day. The highest dose was associated with moderate maternal toxicity. These doses are estimated to be approximately 5,000 times the maximum human ocular daily dose of 2 mg. In the animal studies, no evidence of harm to the fetus due to azithromycin was found. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, azithromycin should be used during pregnancy only if clearly needed.
- Nursing Mothers It is not known whether azithromycin is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when azithromycin is administered to a nursing woman.
 SIDE EFFECTS
Most common adverse reaction reported in patients was eye irritation (1-2% of patients).