Azithromycin (Ophthalmic)

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[edit] BRAND NAMES

[edit] STRUCTURE

Azithromycin.jpg

[edit] MECHANISM OF ACTION

Azithromycin is a macrolide antibiotic, it binds to the 50 S subunit of bacterial ribosomes, inhibiting protein synthesis in bacterial cells.

[edit] INDICATIONS

Azithromycin (Ophthalmic) is indicated for the treatment of bacterial conjunctivitis caused by susceptible isolates of the following microorganisms: CDC coryneform group G, Haemophilus influenzae, Staphylococcus aureus, Streptococcus mitis group, and Streptococcus pneumoniae.

[edit] DOSAGE

1% or 1,5% (15 mg/g) sterile topical ophthalmic solution: Instill 1 drop in the affected eye(s) twice daily, eight to twelve hours apart for the first two days and then instill 1 drop in the affected eye(s) once daily for the next five days

[edit] CONTRAINDICATIONS

Hypersensitivity to any component of the product.

[edit] WARNINGS AND PRECAUTIONS

  • Growth of resistant organisms may occur with prolonged use.
  • Patients should not wear contact lenses if they have signs or symptoms of bacterial conjunctivitis.

[edit] PREGNANCY AND LACTATION

Pregnancy Category B (US). Reproduction studies have been performed in rats and mice at doses up to 200 mg/kg/day. The highest dose was associated with moderate maternal toxicity. These doses are estimated to be approximately 5,000 times the maximum human ocular daily dose of 2 mg. In the animal studies, no evidence of harm to the fetus due to azithromycin was found. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, azithromycin should be used during pregnancy only if clearly needed.

  • Nursing Mothers It is not known whether azithromycin is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when azithromycin is administered to a nursing woman.

[edit] SIDE EFFECTS

Most common adverse reaction reported in patients was eye irritation (1-2% of patients).

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