Bilastine

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[edit] BRAND NAMES

[edit] STRUCTURE

Bilastine.jpg

[edit] MECHANISM OF ACTION

Bilastine is a new second generation (non-sedating) antihistamine. It acts as a highly selective antagonist at peripheral histamine (H1) receptors. Histamine is a substance that causes allergic symptoms. When histamine (H1) receptors are blocked, histamine cannot have its effect, and this leads to a decrease in the symptoms of allergy.

Bilastine lacks anticholinergic effects, doesn't penetrate the blood–brain barrier and impair psychomotor performance or actual driving, and appears to be entirely free from cardiovascular effects.

[edit] INDICATIONS

  • Symptomatic treatment of Urticaria
  • Seasonal and perennial allergic rhinitis to relief symptoms such as sneezing, rhinorrhea and nasal pruritus, occular pruritus and tearing.

[edit] DOSAGE

Adults and adolescents 12 Years of Age and Over: 20 mg once daily (One tablet), on an empty stomach, for example in the morning prior to breakfast. Don't eat for 1 hour after taking bilastine

[edit] CONTRAINDICATIONS

  • Hypersensitivity to Bilastine

[edit] PRECAUTIONS

  • Patients with moderate or severe renal impairment coadministration of bilastine with P-glycoprotein inhibitors, such as e.g, ketoconazole, erythromycin, cyclosporine, ritonavir or diltiazem, may increase plasmatic levels of bilastine and therefore increase the risk of adverse effects of bilastine. Therefore, coadministration of bilastine and P-glycoprotein inhibitors should be avoided in patients with moderate or severe renal impairment.

[edit] INTERACTIONS

  • Food significantly reduces the oral bioavailability of bilastine by 30%.
  • Grapefruit juice: concomitant intake of bilastine 20 mg and grapefruit juice decreased bilastine bioavailability by 30%.

[edit] PREGNANCY AND LACTATION

  • There are no or limited amount of data from the use of bilastine in pregnant women. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity, parturition or postnatal development. As a precautionary measure, it is preferable to avoid the use during pregnancy.
  • Lactation: It is unknown whether bilastine is excreted in human breast milk. The excretion of bilastine in milk has not been studied in animals. A decision on whether to continue/discontinue breastfeeding or to continue/discontinue therapy with Bilastine should be made taking into account the benefit of breastfeeding to the child and the benefit of bilastine therapy to the mother.

[edit] SIDE EFFECTS

  • Common side effects (1-10% users): Headache and drowsiness
  • Uncommon side effects (0,1-1% users): Abnormal ECG heart tracing, abnormal liver function tests, dizziness, stomach pain, tiredness and weakness, increased appetite, irregular heartbeat, increased weight, nausea, anxiety, dry nose, back pain, diarrhea, gastritis, dry mouth and thirst, dyspnea, indigestion, cold sores, fever, tinnitus and insomnia

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES