Pheniramine

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[edit] BRAND NAMES

[edit] STRUCTURE

Pheniramine.jpg

[edit] MECHANISM OF ACTION

Pheniramine is an antihistamine with anticholinergic and central sedative properties. Histamine is a substance that causes allergic symptoms. When histamine (H1) receptors are blocked, histamine cannot have its effect, and this leads to a decrease in the symptoms of allergy.

[edit] INDICATIONS

Allergic conditions ( hypersensitivity reactions) such as:

  • Hay fever (pollinosis) with attacks of sneezing, itching, and running of the nose, conjunctivitis
  • Urticaria with pruritus, reddening, wealing, and swelling of the skin.
  • Eczema of nervous origin (neurodermatitis) with pruritus

The injection solution is suitable for the treatment of severe hypersensitivity reactions and pruritus of varying origin and where oral treatment is not practicable.

[edit] DOSAGE

  • Retard dragees: In most adults and adolescents over 12 years old, one 75 mg dragee taken at bed time is sufficient. Only in very resistant cases, and then only for a short time, an additional dragee is taken in the morning after breakfast. Retard dragees are swallowed whole with a little liquid after meals.
  • Syrup (15mg/5ml):
    • Children aged 1-3 years : half a measuring spoonful 2 or 3 times daily
    • Children aged 4-12 years: 1 measuring spoonfuls of syrup, 2 or 3 times daily.
    • Adults and adolescents: 1-2 measuring spoonfuls of syrup 2 or 3 times daily. A daily dose of 3mg/kg body weight must not be exceeded.
  • Injection (22,75mg/ml vials): 1-2ml twice a day by intramuscular or slow intravenous injection.

[edit] CONTRAINDICATIONS

  • Hypersensitivity to pheniramine.
  • Prostatic hypertrophy with residual urine formation.

[edit] PRECAUTIONS

  • Even if used according to prescription, Pheniramine may reduce alertness to such an extent that the ability to cope with street traffic or operate machinery is impaired

[edit] INTERACTIONS

The effect of drugs which act on the central nervous system e.g.: tranquilizers and hypnotics, MAO inhibitors, or of alcohol may be potentiated.

[edit] PREGNANCY AND LACTATION

  • Pregnancy: Pheniramine should be used only if strictly indicated and after considering the benefit / risk ratio for the mother and the child.

[edit] SIDE EFFECTS

  • Occasionally, there may be drowsiness, gastrointestinal complaints, dryness of mouth, palpitations, urinary retentions or hypersensitivity reactions.
  • In isolated cases, higher dosage may produce hallucinations, restlessness, or confusion.
  • In patients with narrow-angle glaucoma, a rise in intraocular pressure is possible, which makes ophthalmologic control necessary.

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES