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 BRAND NAMES
 MECHANISM OF ACTION
- Lubiprostone is a prostaglandin E1 derivative. It increases chloride ion transport into the intestinal lumen, enhances fluid secretion into the bowels, and improves fecal transit.
- Treatment of chronic idiopathic constipation in adults
- Treatment of opioid-induced constipation in adults with chronic, non-cancer pain. Limitations of Use: Effectiveness of Amitiza in the treatment of opioid-induced constipation in patients taking diphenylheptane opioids (e.g., methadone) has not been established
- Treatment of irritable bowel syndrome with constipation in women ≥ 18 years old
- Chronic Idiopathic Constipation and Opioid-induced Constipation: 24 mcg taken twice daily orally with food and water
- Irritable Bowel Syndrome with Constipation: 8 mcg taken twice daily orally with food and water.
 DOSAGE FORMS AND STRENGTHS
- Capsules: 8 mcg and 24 mcg
- Patients with known or suspected mechanical gastrointestinal obstruction.
 WARNINGS AND PRECAUTIONS
- Patients may experience nausea; concomitant administration of food may reduce this symptom
- Do not prescribe for patients that have severe diarrhea
- Patients taking Lubiprostone may experience dyspnea within an hour of first dose. This symptom generally resolves within 3 hours, but may recur with repeat dosing.
- Evaluate patients with symptoms suggestive of mechanical gastrointestinal obstruction prior to initiating treatment with Lubiprostone
Concomitant use of diphenylheptane opioids (e.g., methadone) may interfere with the efficacy of Lubiprostone
 PREGNANCY AND LACTATION
- Pregnancy Category C (US): Based on animal data, Lubiprostone may cause fetal harm and should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
- Nursing Mothers: Caution should be exercised when administering to a nursing woman
 SIDE EFFECTS
Most common adverse reactions (incidence > 4%) are nausea, diarrhea, abdominal pain, abdominal distension, flatulence
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