| Click on "►" to expand:|
 BRAND NAMES
- International: Phyllocontin, Truphylline
- Italy: Aminomal, Tefamin
 MECHANISM OF ACTION
Aminophylline is a complex of theophylline-ethylenediamine, it has greater water solubility than Theophylline. Therefore it is particularly suitable for both oral and parenteral administration.
Compared to theophylline, Aminophylline is less potent and has a shorter duration of action. They have both the same mechanism of action; they work as a bronchodilator by the relaxation of bronchial smooth muscle by inhibiting phosphodiesterase, an enzyme that catalyzes the conversion of cAMP in 5 AMP, with resultant cAMP accumulation.
Recently, many clinical and experimental investigations have shown their ability to inhibits the release of inflammatory mediators (histamine) from mast cells. Additionally, they may improve diaphragm muscle contractility and stimulate the medullary respiratory center.
- Treatment and prophylaxis of bronchospasm associated with asthma, chronic obstructive pulmonary diseases and chronic bronchitis.
- Treatment of left ventricular and congestive cardiac failure in adults
Adult, Bronchospasm: orally, 200mg 4 times a day. maximum 400mg 4 times a day.
- Hypersensitivity to xanthines
- Use with caution in patients with cardiac arrhythmias, peptic ulcer, hyperthyroidism, severe hypertension, hepatic dysfunction, chronic alcoholism or acute febrile illness.
- In the elderly, the half-life of Aminophylline may be prolonged (A reduction of dosage may be necessary).
- Avoid in patients with a history of seizure activity
 PREGNANCY AND LACTATION
Pregnancy category C. Aminophylline should not be administered during pregnancy unless clearly necessary.
Aminophylline is secreted in breast milk and may be associated with irritability in the infant; therefore it should only be given to breast feeding women when the anticipated benefits outweigh the risk to the child.
 SIDE EFFECTS
Nausea, gastric irritation, headache, hypokalemia, CNS stimulation, tachycardia, palpitations, arrhythmias and convulsions