BRAND NAMES
- International: Allegra, Telfast
- Australia: Allerfexo
- Italy: Telfast, Fixodin
- Poland: Telfexo
- U.S.: Allegra PI
 MECHANISM OF ACTION
Fexofenadine the major active metabolite of the H1 receptor antagonist terfenadine (Withdrawn due to ventricular arrhythmias) is a second generation antihistamine with selective peripheral H1-receptor antagonist activity (it does not cross the blood-brain barrier).
Histamine is a substance that causes allergic symptoms. When histamine (H1) receptors are blocked, histamine cannot have its effect, and this leads to a decrease in the symptoms of allergy.
Fexofenadine is rapidly absorbed (onset of relief < or = 2 hours) and has a long duration of action, making it suitable for once daily administration.
Fexofenadine is indicated for the relief of symptoms associated with allergic rhinitis and chronic idiopathic urticaria.
- Adults and Children 12 Years and Older: 60 mg twice daily or 180 mg once daily, before a meal. Do not exceed the recommended dose.
- Children 6 to 11 years: 30 mg twice daily
- Children 2 to 5 years: 30 mg twice daily
- Children 6 months to less than 2 years: 15 mg twice daily
- Known hypersensitivity to Fexofenadine
- Antacids: Fexofenadine should not be taken closely in time with aluminum and magnesium containing antacids.
- Fruit juice: Fruit juices such as grapefruit, orange and apple may reduce the bioavailability and exposure of fexofenadine. Take Fexofenadine with water.
 PREGNANCY AND LACTATION
- Pregnancy Category C (US): Fexofenadine should be used in pregnancy or lactation only if the potential benefit justifies the potential risk to the fetus or nursing infant.
- Nursing Mothers: It is not known if fexofenadine is excreted in human milk. There are no adequate and well-controlled studies in women during lactation. Because many drugs are excreted in human milk, caution should be exercised when fexofenadine hydrochloride is administered to a nursing woman.
 SIDE EFFECTS
The most common adverse reactions are headache, somnolence, dizziness, and stomach discomfort.
 RELATED LINKS
|For systemic use||Bilastine • Cetirizine • Chlorphenamine • Cyproheptadine • Dexchlorpheniramine • Desloratadine • Dimetindene (Oral route) • Ebastine • Fexofenadine • Ketotifen (Oral route) • Levocetirizine • Loratadine • Mequitazine • Mizolastine • Oxatomide (Oral route) • Rupatadine|
|For topical use||Dexchlorpheniramine (Topical) • Diphenhydramine • Dimetindene (Topical) • Oxatomide (Topical) • Promethazine|
|Nasal spray||Azelastine (Nasal spray) • Levocabastine (Nasal spray)|
|Eye drops||Azelastine (Eye drops) • Epinastine • Ketotifen (Eye drops) • Levocabastine (Eye drops) • Olopatadine (Eye drops)|
|Combinations||Cetirizine/Pseudoephedrine • Desloratadine/Pseudoephedrine|