Alfuzosin

From Drugs Prescribing Information
Jump to: navigation, search

Contents

[edit] BRAND NAMES

[edit] STRUCTURE

Alfuzosin.jpg

[edit] MECHANISM OF ACTION

Alfuzosin exerts a selective postsynaptic action, inhibiting the binding of norepinephrine to the α1 receptors.

Three α1 receptor subtypes have been identified, α1a, α1b and α1d:

  • α1a and α1d subtypes are predominant in the prostate, bladder, and detrusor muscle.
  • α1b subtypes are largely located on vascular smooth muscle.

Alfuzosin antagonizes all three subtypes; blockade of α1a and α1d can lead to smooth muscle relaxation in the lower urinary tract resulting in improved urinary flow rates. At the same time blockade of α1b subtypes can cause relaxation in peripheral vascular resistance which results in a decrease in blood pressure.

[edit] INDICATIONS

Treatment of the signs and symptoms of benign prostatic hyperplasia

[edit] DOSAGE

Extended-release tablets: The recommended dosage is one 10 mg extended-release tablet daily to be taken immediately after the same meal each day. Unlike most other Alpha 1 antagonists (e.g. Doxazosin, Prazosin), a low risk of first-dose effect is seen with Alfuzosin, conveniently eliminating the necessity of dose titration.

[edit] CONTRAINDICATIONS

  • Hypersensitivity to Alfuzosin
  • Patients with moderate or severe hepatic insufficiency
  • Co-administration with potent CYP3A4 inhibitors such as ketoconazole, itraconazole, and ritonavir, since alfuzosin blood levels are increased

[edit] WARNINGS AND PRECAUTIONS

  • Postural hypotension, dizziness, lightheadedness and syncope can occur, especially at initiation of therapy.
  • Patients should be screened for the presence of prostate cancer prior to treatment and at regular intervals afterwards because prostate cancer causes many of the symptoms associated with BPH and the two disorders frequently co-exist.

[edit] INTERACTIONS

  • Concomitant administration of Alfuzosin with a PDE5 inhibitor (Viagra, Levitra, Cialis, Stendra) can result in additive blood pressure lowering effects and symptomatic hypotension.

[edit] PREGNANCY AND LACTATION

[edit] SIDE EFFECTS

The most commonly adverse reactions are asthenia, headache, and dizziness

[edit] RELATED LINKS

Benign Prostatic Hyperplasia (BPH) and Treatments (Video 1)
Benign Prostatic Hyperplasia (BPH) and Treatments (Video 2)

[edit] BIBLIOGRAPHY

[edit] REFERENCES

Benign Prostatic Hypertrophy
5α reductase inhibitors Dutasteride (Avodart)   Finasteride (Proscar)
Alpha 1 antagonists Alfuzosin (Uroxatral, Xatral)   Doxazosin (Cardura)   Prazosin   Silodosin (Silodyx, Rapaflo)   Tamsulosin (Omnic, Flomax, Secotex)   Terazosin (Hytrin)
Phytotherapy Pygeum africanum   Serenoa repens
PDE5 inhibitors Tadalafil (Cialis)
Combination products Dutasteride/Tamsulosin (Combodart, Jalyn, Duodart)
Other Mepartricin
Veterinary Osaterone (Ypozane)