Albendazole

From Drugs Prescribing Information
Jump to: navigation, search

Click on "►" to expand:

Albendazole (Zentel, Albenza) is used to clear worms or parasites from the gut and other tissues.

Albendazole is effective against threadworm or pinworm, roundworm, whipworm, tapeworm and hookworm among others.

Albendazole is thought to kill these worms by causing them to starve. The eggs, larvae and adult worms are affected.

Contents

[edit] BRAND NAMES

[edit] STRUCTURE

Albendazole.jpg

[edit] MECHANISM OF ACTION

Albendazole is a benzimidazole carbamate with anthelmintic and antiprotozoal activity.

Albendazole acts by:

  • Inhibiting tubulin polymerization into microtubules due to its high affinity for parasite β-tubulin. This causes an impaired uptake of glucose, leading to depletion of glycogen, and reduced stores of ATP, and thus, energy depletion, which immobilizes and then kills the susceptible helminth.
  • Inhibiting helminth-specific fumarate reductase.

[edit] INDICATIONS

Nematodes:

  • Roundworm (Ascaris lumbricoides)
  • Pinworm (US) called also Threadworm (UK) (Enterobius vermicularis)
  • Hookworm (Necator americanus, Ancylostoma duodenale)
  • Whipworm (Trichuris trichiura)
  • Cutaneous larva migrans ( Ancylostoma braziliense)
  • Strongyloidiasis (Strongyloides stercoralis)
  • Filariasis


Cestodes (Tapeworms):

  • Taenia spp (T.solium, T.saginata)
  • Hymenolepis nana
  • Cystic echinococcosis (Echinococcus granulosus)
  • Alveolar echinococcosis (Echinococcus multilocularis)

[edit] DOSAGE

Indications Age Dose Period
Roundworm (Ascaris lumbricoides) Adults and Children (over two years) 400mg  single dose

(US) Pinworm (Enterobius vermicularis)

(UK) Threadworm (Enterobius vermicularis)

Adults and Children (over two years) 400mg  single dose
Hookworm (Necator americanus, Ancylostoma duodenale) Adults and Children (over two years) 400mg single dose
Whipworm (Trichuris trichiura) Adults and Children (over two years) 400mg single dose
Cutaneous larva migrans ( Ancylostoma braziliense) Adults and Children (over two years) 400mg
one dose per 
day for 3 days
Filariasis


Taenia spp (T.solium, T.saginata) Adults and Children (over two years) 400mg
one dose per 
day for 3 days
Strongyloidiasis (Strongyloides stercoralis) Adults and Children (over two years) 400mg
one dose per 
day for 3 days
Hymenolepis nana Adults and Children (over two years) 400mg
one dose per 
day for 3 days

If the patient is not cured after three weeks, a second course of 
Albendazole treatment is indicated.

[edit] CONTRAINDICATIONS

  • Hypersensitivity to the drug
  • Albendazole should not be administered during pregnancy, or in women thought to be pregnant.

[edit] PRECAUTIONS

In order to avoid administering Albendazole during early pregnancy, women of childbearing age should initiate treatment during the first week of menstruation or after a negative pregnancy test.

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

  • Pregnancy: Albendazole should not be administered during pregnancy or in women thought to be pregnant
  • Lactation: Albendazole should not be used during lactation unless the potential benefits are considered to outweigh the potential risks associated with treatment.

[edit] SIDE EFFECTS

Albendazole may cause the following side effects:

  • Gastrointestinal tract: Abdominal pain, liver dysfunction, nausea, vomiting and diarrhoea (Uncommon)
  • Hemopoietic system: Bone marrow suppression, aplastic anemia, and agranulocytosis
  • CNS: headache and dizziness (Uncommon)
  • Other: Hypersensitvity reactions including rash, pruritis and urticaria (Rarely)

[edit] RELATED LINKS

[edit] REFERENCES