Loratadine

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[edit] BRAND NAMES

[edit] STRUCTURE

Loratadine.jpg

[edit] MECHANISM OF ACTION

Loratadine is long-acting tricyclic second generation (non-sedating) antihistamine. It acts as an antagonist at peripheral histamine (H1) receptors. Histamine is a substance that causes allergic symptoms. When histamine (H1) receptors are blocked, histamine cannot have its effect, and this leads to a decrease in the symptoms of allergy.

As with other second-generation antihistamines, the low incidence of sedation can be attributed to reduced penetration into the CNS

[edit] INDICATIONS

  • Chronic Idiopathic Urticaria
  • Seasonal and perennial allergic rhinitis to relief symptoms such as sneezing, rhinorrhea and nasal pruritus, occular pruritus and tearing.

[edit] DOSAGE

  • Adults and children 6 Years of Age and Over: 10 mg once daily
  • Children 2 to 5 Years of Age: 5 mg once daily with or without a meal

[edit] CONTRAINDICATIONS

Hypersensitivity to loratadine.

[edit] WARNINGS AND PRECAUTIONS

  • Somnolence has been reported very rarely in patients taking Loratadine. Caution should be exercised when driving a car or operating potentially dangerous machinery.
  • Rare cases of hypersensitivity reactions (such as rash, pruritus, urticaria, edema, dyspnea, and anaphylaxis) have been reported. In such cases, stop the drug at once and consider alternative treatments.

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

  • Pregnancy Category B (US). Loratadine should be used during pregnancy only if clearly needed.
  • Nursing Mothers: Loratadine and its metabolite (Desloratadine), pass easily into breast milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Caution should be exercised if administered to a nursing woman.

[edit] SIDE EFFECTS

Most common adverse reactions are dry mouth, fatigue, somnolence and headache.

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES