Agomelatine

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Contents

[edit] BRAND NAMES

[edit] STRUCTURE

Agomelatine.jpg

[edit] MECHANISM OF ACTION

Agomelatine is a 5HT2c receptors antagonist localized on dopaminergic and noradrenergic nerve terminals. The blockade of this receptor increases noradrenaline and dopamine release in the synaptic space, specifically in the frontal cortex.

[edit] INDICATIONS

Treatment of major depressive episodes in adults

[edit] DOSAGE

Adults: 25 mg once daily taken orally with or without food at bedtime. If there is no improvement of symptoms after two weeks of treatment, the dose may be increased to 50 mg once daily at bedtime. Patients should be treated for a sufficient period of at least 6 months.

[edit] CONTRAINDICATIONS

[edit] PRECAUTIONS

  • Increased serum transaminases have been observed in patients treated with agomelatine. Liver function tests should be performed in all patients at initiation of treatment and then periodically after around six weeks, twelve and twenty four weeks and thereafter when clinically indicated.

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

As a precautionary measure, it is preferable to avoid the use of Agomelatine during pregnancy. During lactation, If treatment with Agomelatine is considered necessary, breastfeeding should be discontinued.

[edit] SIDE EFFECTS

The most common adverse reactions, usually transient, were: nausea, dizziness and headache.

Dose escalation was associated with an increase in liver function abnormalities.

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES

Antidepressants
Tricyclic antidepressants Amitriptyline (Elavil, Laroxyl)   Clomipramine (Anafranil)   Doxepin (Sinequan)   Imipramine (Tofranil)   Nortriptyline (Aventyl, Pamelor)   Trimipramine (Surmontil)
Selective serotonin reuptake inhibitors (SSRIs) Citalopram (Celexa, Seropram)   Escitalopram (Cipralex, Lexapro)   Fluoxetine (Prozac)   Fluvoxamine (Luvox, Maveral)   Paroxetine (Paxil, Seroxat)   Sertraline (Zoloft)
Serotonin–norepinephrine reuptake inhibitors (SNRIs) Desvenlafaxine (Pristiq)   Duloxetine (Cymbalta, Xeristar)   Venlafaxine (Efexor, Effexor)
Serotonin antagonists and reuptake inhibitors (SARIs) Trazodone (Desyrel, Oleptro)
Norepinephrine reuptake inhibitors (NRIs) Maprotiline (Ludiomil)   Reboxetine (Edronax)
Norepinephrine-dopamine reuptake inhibitors (NDRIs) Bupropion (Wellbutrin)
Noradrenergic and specific serotonergic antidepressants (NaSSAs) Mianserin (Lantanon)   Mirtazapine (Remeron)
Norepinephrine-dopamine disinhibitors (NDDIs) Agomelatine (Valdoxan, Thymanax)
Monoamine oxidase inhibitors Nonselective Tranylcypromine (Parnate)
Monoamine oxidase inhibitors B-Selective Selegiline (Transdermal) (Emsam)
Others 5-Hydroxytryptophan   S-Adenosyl methionine   Hypericum (St John's wort)