BRAND NAMES
- Belgium: Aerinaze
- Canada: Aerius Dual Action 12 Hour
- U.S.: Clarinex-D 24 Hour PI, Clarinex-D 12 Hour PI
 MECHANISM OF ACTION
Desloratadine is long-acting tricyclic second generation (non-sedating) antihistamine. It is the active metabolite of loratadine and produces the same pharmacologic effect; both antagonist at peripheral histamine (H1) receptors. Histamine is a substance that causes allergic symptoms. When histamine (H1) receptors are blocked, histamine cannot have its effect, and this leads to a decrease in the symptoms of allergy.
As with other second-generation antihistamines, the low incidence of sedation can be attributed to reduced penetration into the CNS
Pseudoephedrine, one of the naturally occurring alkaloids of Ephedra and an orally administered vasoconstrictor, is a sympathomimetic drug that produces a gradual but sustained decongestant effect facilitating shrinkage of congested mucosa in upper respiratory areas.
Relief of symptoms of seasonal allergic rhinitis when both the antihistaminic properties and the nasal decongestant activity are desired
Adults and Children 12 years of age and over: One Loratadine/Pseudoephedrine tablet (Desloratadine 2,5mg/Pseudoephedrine 120 mg) every 12 hours; not more than 2 tablets in 24 hours OR One Loratadine/Pseudoephedrine tablet (Desloratadine 5mg/Pseudoephedrine 240mg) once daily
- Hypersensitivity to Desoratadine or to Pseudoephedrine .
- Patients receiving MAO inhibitor therapy or within fourteen days of discontinuing such treatment
- Patients with narrow-angle glaucoma
- Urinary retention
- Severe hypertension
- Severe coronary artery disease
 WARNINGS AND PRECAUTIONS
- Cardiovascular and central nervous system effects: Use with caution in patients with cardiovascular disorders.
- Coexisting conditions: Use with caution in patients with increased intraocular pressure, prostatic hypertrophy, diabetes mellitus, or hyperthyroidism.
- Monoamine Oxidase (MAO) Inhibitors: Do not use. May potentiate the effect of pseudoephedrine on vascular system; hypertensive reactions, including hypertensive crises, may occur.
 PREGNANCY AND LACTATION
- Pregnancy Category C (US). Desloratadine/Pseudoephedrine combination should be used during pregnancy only if clearly needed.
- Since Desloratadine and pseudoephedrine are excreted in breast milk, a decision should be made whether to discontinue nursing or to discontinue the use of this product.
 SIDE EFFECTS
The most common adverse reactions were insomnia, headache, mouth dry, fatigue, somnolence, pharyngitis, dizziness, nausea, nervousness, and anorexia.
 RELATED LINKS
|For systemic use||Bilastine • Cetirizine • Chlorphenamine • Cyproheptadine • Dexchlorpheniramine • Desloratadine • Dimetindene (Oral route) • Ebastine • Fexofenadine • Ketotifen (Oral route) • Levocetirizine • Loratadine • Mequitazine • Mizolastine • Oxatomide (Oral route) • Rupatadine|
|For topical use||Dexchlorpheniramine (Topical) • Diphenhydramine • Dimetindene (Topical) • Oxatomide (Topical) • Promethazine|
|Nasal spray||Azelastine (Nasal spray) • Levocabastine (Nasal spray)|
|Eye drops||Azelastine (Eye drops) • Epinastine • Ketotifen (Eye drops) • Levocabastine (Eye drops) • Olopatadine (Eye drops)|
|Combinations||Cetirizine/Pseudoephedrine • Desloratadine/Pseudoephedrine|