BRAND NAMES
- Australia: Serepax PI
- Belgium: Tranquo
- Germany: Adumbran, Praxiten
- India: Serepax, Zaxpam
- Israel: Vaben
- Italy: Serpax
- Switzerland: Seresta
 MECHANISM OF ACTION
Oxazepam, like other Benzodiazepines bind to specific sites on the gamma-aminobutyric acid-A (GABAA) receptors. This enhances the effects of GABA by increasing its affinity for the GABAA receptor.
Activation of the GABAA receptor, which is linked to a chloride channel (Cl-), results in an influx of Cl- into the neurone causing hyperpolarisation, which results in inhibitory effects on the central nervous system.
Benzodiazepines action on GABAA receptors appears to produce their anxiolytic, sedative, muscle relaxant, hypnotic and anticonvulsant actions.
Oxazepam is a short to intermediate acting benzodiazepine, its half-life in human plasma ranges from 4 to 15 hours and peak concentrations in plasma occur approximately 2-3 hours following administration of 30 mg.
Treatment of anxiety disorder, or trembling, confusion or anxiety associated with alcohol withdrawal.
Note that anxiety or tension associated with the normal stress of everyday life usually does not require treatment with benzodizepines.
- Adults: For mild to moderate anxiety, the usual dose is 7.5-15 mg, 3 or 4 times daily. For severe anxiety syndromes, agitation or anxiety associated with depression, the usual dose is 15-30 mg, 3 or 4 times daily.
- Elderly or debilitated patients, including those with hepatic and / or renal disease: the starting dose is 15 mg, 1 or 2 times a day. If necessary, the dosage may be increased up with caution to 15 mg, 3 or 4 times a day.
- Alcoholics with tremulousness or anxiety on withdrawal: the usual dose is 15-30 mg, 3 or 4 times daily.
- Hypersensitivity to Oxazepam or to any drug in the benzodiazepine class
- Pregnancy and lactation
- Myasthenia gravis (Oxazepam could increase the muscle weakness)
- Severe respiratory failure or sleep apnea syndrome
- Do not drive or do other dangerous activities after taking Oxazepam until you feel fully awake.
- Do not drink alcohol
- Following the prolonged use of Oxazepam at therapeutic doses withdrawal from the medication should be gradual.
Benzodiazepines, including Oxazepam, produce additive CNS depressant effects when co-administered with other medications which themselves produce CNS depression (e.g. barbiturates, alcohol, sedatives, tricyclic antidepressants, antipsychotics, skeletal muscle relaxants, antihistamines or narcotic analgesics and anaesthetics).
 PREGNANCY AND LACTATION
Not reccomended during pregnancy and lactation
 SIDE EFFECTS
Common side effects include: drowsiness, headache, dizziness, lightheadedness, difficulty with coordination.
 RELATED LINKS
|Sedatives / Hypnotics / Anxiolytics|
|Benzodiazepines||Benzodiazepines (Anxiolytics)||Alprazolam (Xanax) • Bromazepam (Lexotan, Lexotanil) • Chlordiazepoxide (Librium) • Clobazam (Frisium) • Clorazepate (Tranxene) • Clotiazepam (Rizen, Tienor) • Delorazepam (EN) • Diazepam (Valium) • Etizolam (Depas) • Ketazolam • Lorazepam (Ativan, Control, Lorans, Tavor, Temesta) • Lormetazepam (Noctamid) • Nordazepam (Nordaz) • Oxazepam (Serepax) • Prazepam (Demetrin, Lysanxia)|
|Benzodiazepines (Hypnotics)||Brotizolam (Lendormin, Bondormin, Dormex, Sintonal, Noctilan) • Clobazam (Frisium) • Estazolam (Esilgan, ProSom) • Etizolam (Depas, Pasaden, Etilaam, Etizest) • Flunitrazepam (Rohypnol) • Flurazepam (Dalmadorm, Dalmane, Felison, Flunox, Valdorm) • Ketazolam (Anseren, Anxon) • Lorazepam (Ativan, Control, Lorans, Tavor, Temesta) • Lormetazepam (Loramet, Minias, Noctamid, Pronoctan, Evamyl) • Midazolam (Dormicum, Hypnovel) • Nitrazepam (Mogadon, Nitrados, Numbon, Radedorm, Alodorm) • Nordazepam (Madar, Nordaz, Stilny, Tranxilium N) • Temazepam (Normison, Restoril, Tenox, Temaze) • Triazolam (Halcion, Hypam, Rilamir)|
|Non-Benzodiazepine Hypnotics||Eszopiclone (Lunesta) • Zolpidem (Ambien, Stilnox, Hypnogen, Sanval, Stilnoct, Zoldem, Zolsana) • Zopiclone (Imovane, Zimovane)|
|Melatonin agonists||Melatonin (Circadin) • Ramelteon (Rozerem)|
|Orexin agonists||Suvorexant (Belsomra)|