Thiocolchicoside

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[edit] BRAND NAMES

[edit] STRUCTURE

Thiocolchicoside.jpg

[edit] MECHANISM OF ACTION

Thiocolchicoside acts as a muscle relaxant especially on striated muscles. It acts as a competitive GABA(A) receptor antagonist in the central nervous system.

[edit] INDICATIONS

All types of muscular contractures, low back pain, dorsal pain, torticollis and spasms associated with traumatological and neurological disorders

[edit] DOSAGE

  • Severe muscular contracture: 4 mg injection twice a day for 3-5 days, eventually continued by oral route at the dosage of two 4mg capsules, twice a day for 5-7 days. Tablets should be taken on a full stomach
  • Mild to moderate muscular contracture: two 4mg capsules o one 8 mg capsule, twice a day for 5-7 days. Tablets should be taken on a full stomach

[edit] CONTRAINDICATIONS

  • Hypersensitivity to thiocolchicoside.
  • Pregnancy and lactation

[edit] PRECAUTIONS

  • Thiocolchicoside has powerful convulsant activity and should not be used in seizure-prone individuals
  • The dose should be reduced in case of diarrhea.
  • Care should be exercised when driving and operating machinery

[edit] INTERACTIONS

[edit] PREGNANCY AND LACTATION

  • Pregnancy: Administration during pregnancy is not recommended.
  • Lactation: Thiocolchicoside is not advised in women during lactation since it is excreted in mother's milk.

[edit] SIDE EFFECTS

  • Gastsrointestinal system: Gastralgia and diarrhea after oral administration
  • Hypersensitivity : Allergic reactions, anaphylactic reactions such as itching, rash, angioedema, bronchospasm or even anaphylactic shock occur rarely.

[edit] RELATED LINKS

[edit] BIBLIOGRAPHY

[edit] REFERENCES