BRAND NAMES
- Others: Adaferin
 MECHANISM OF ACTION
Adapalene, is a synthetic retinoid, It binds to retinoic acid receptors found predominantly in the terminal differentiation zone of epidermis and acts as a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris. Adapalene is more active than tretinoin in modulating cellular differentiation.
- Topical treatment of acne vulgaris
- The 0.3% topical gel is indicated for the topical treatment of acne vulgaris in patients 12 years of age and older (FDA)
Apply a thin film, using enough to cover the entire affected areas of the skin, once daily at nighttime. A mild transitory sensation of warmth or slight stinging may occur shortly after the application
- Hypersensitivity to adapalene
 WARNINGS AND PRECAUTIONS
- Avoid exposure to sunlight and sunlamps. Wear sunscreen when sun exposure cannot be avoided
- Avoid contact with the eyes, lips, angles of the nose, and mucous membranes
- Erythema, dryness, scaling, burning, or pruritus may be experienced. These are most likely to occur during the first two to four weeks of treatment and usually lessen with continued use of the medication. Depending upon the severity of these side effects, patients should be instructed to reduce the frequency of application or discontinue the drug.
Concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol, astringents, spices or lime rind) should be approached with caution.
 PREGNANCY AND LACTATION
- Pregnancy Category C (US). Retinoids may cause fetal harm, when administered to pregnant women. Adapalene has been shown to be teratogenic in rats and rabbits when administered orally. There are no adequate and well-controlled studies in pregnant women. Adapalene should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
- Nursing Mothers: It is not known whether adapalene is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised if the drug is administered to a nursing woman.
 SIDE EFFECTS
The most frequently reported adverse reactions were dry skin, skin discomfort, pruritus, desquamation, and sunburn
 RELATED LINKS
|Oral antibiotics||Clindamycin (Oral route) • Doxycycline • Erythromycin (Oral route) • Josamycin • Lymecycline • Minocycline • Tetracycline|
|Topical antibiotics||Clindamycin (Topical) • Erythromycin (Topical)|
|Topical retinoids||Adapalene • Tazarotene • Tretinoin|
|Oral retinoids||Isotretinoin (Oral)|
|Oral contraceptives||Estradiol valerate/Dienogest • Ethinyl Estradiol/Cyproterone acetate|
|Topical Antibacterial/Keratolytic||Benzoyl peroxide • Hydrogen Peroxide Cream|
|Topical combination products||Clindamycin/Benzoyl peroxide • Adapalene/Benzoyl peroxide • Clindamycin/Tretinoin • Miconazole/Benzoyl peroxide • Erythromycin/Benzoyl peroxide • Erythromycin/Isotretinoin|