Miconazole/Benzoyl peroxide

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Contents

[edit] BRAND NAMES

[edit] STRUCTURE

[edit] MECHANISM OF ACTION

Miconazole, a broad-spectrum fungicide, is also bactericidal against Staphylococcus aureus and Propionibaererium acnes

Benzoyl peroxide is an antibacterial agent which has been shown to be effective against Propionibacterium acnes. This action is believed to be responsible for its usefulness in acne.
Benzoyl peroxide, exerts also a desquamative action and provides mild peeling and keratolytic activity.

In vitro studies demonstrate a synergistic mechanism of action in the inhibition of Staphylococcus spp. and Propionibacterium acnes.

[edit] INDICATIONS

Topical treatment of acne vulgaris

[edit] DOSAGE

A thin layer should be applied to the affected areas once daily (evening) during the first week and twice daily (morning and evening) thereafter. Washing the face with mild soap and lukewarm water prior to application enhances the efficacy of the medication.

Treatment should be continued until symptoms have disappeared (normally between 4 and 8 weeks). Then, especially in patients younger than 18 years of age, it is advisable to maintain the treatment with less frequent applications (2 - 3 times a week) to ensure improvement.

Patients with widespread facial acne should only apply the product to a small area for the first few days. If this is well tolerated, larger areas can then be treated.

[edit] CONTRAINDICATIONS

  • Hypersensitivity to Miconazole or to Benzoyl peroxide

[edit] PRECAUTIONS

  • Avoid exposure to sunlight and sunlamps. Wear sunscreen when sun exposure cannot be avoided
  • The product may bleach dyed clothing and fabrics.

[edit] PREGNANCY AND LACTATION

[edit] SIDE EFFECTS

  • After application there may be transient stinging or burning sensations, which disappear after continued use. Vasodilation and perivascular lymphocytic infiltration occur. It is especially irritating to skin on the neck and circumoral areas. It must be kept away from the eyes and mucous membranes. Excess dryness of the skin and desquamation may occur after 1 or 2 weeks of use. Benzoyl peroxide can cause dermatitis.
  • Mild irritation and/or moderate reddening may appear, especially at the beginning of treatment.
  • True contact allergy to benzoyl peroxide or miconazole may be encountered.

[edit] RELATED LINKS

Acne Treatments

[edit] BIBLIOGRAPHY

[edit] REFERENCES

Acne
Oral antibiotics Clindamycin (Oral route)   Doxycycline   Erythromycin (Oral route)   Josamycin   Lymecycline   Minocycline   Tetracycline
Topical antibiotics Clindamycin (Topical)   Erythromycin (Topical)
Topical retinoids Adapalene   Tazarotene   Tretinoin
Oral retinoids Isotretinoin (Oral)
Oral contraceptives Estradiol valerate/Dienogest   Ethinyl Estradiol/Cyproterone acetate
Topical Antibacterial/Keratolytic Benzoyl peroxide   Hydrogen Peroxide Cream
Topical combination products Clindamycin/Benzoyl peroxide   Adapalene/Benzoyl peroxide   Clindamycin/Tretinoin   Miconazole/Benzoyl peroxide   Erythromycin/Benzoyl peroxide   Erythromycin/Isotretinoin