BRAND NAMES
- Canada: Retrovir Product Monograph/Monographie
- Europe: Retrovir
- International: Retrovir
- US: Retrovir Oral PI, Injection PI
 MECHANISM OF ACTION
Zidovudine or azidothymidine (AZT) is a nucleoside analog reverse-transcriptase inhibitor (NRTI). It is a thymidine analogue and works by selectively inhibiting HIV's reverse transcriptase, the enzyme that the virus uses to make a DNA copy of its RNA.
Zidovudine is used for the treatment of HIV/AIDS infection. HIV can develop resistance to AZT by mutation of its reverse transcriptase. To slow the development of resistance, Zidovudine is given in combination with another reverse transcriptase inhibitor and an antiretroviral from another group, such as a protease inhibitor or a non-nucleoside reverse transcriptase inhibitor; this type of therapy is known as HAART (Highly Active Anti Retroviral Therapy).