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 BRAND NAMES
 MECHANISM OF ACTION
Phenazopyridine is excreted in the urine where it exerts a topical analgesic effect on the mucosa of the urinary tract
Phenazopyridine relieves lower urinary symptoms of pain, frequency, urgency, burning and dysuria, arising from inflammation of the urothelium, the mucosal lining of the lower urinary tract caused by infection, trauma, surgery, endoscopic procedures, or the passage of sounds or catheters.
Adults: 200 mg 3 times daily, with or following food or after eating a snack to reduce stomach upset.
When used concomitantly with an antibiotic for the treatment of a urinary tract infection, the administration of phenazopyridine should not exceed 2 days. If symptoms persist, the patient should be re-evaluated.
- Patients who have previously exhibited hypersensitivity to Phenazopyridine.
- Patients with renal insufficiency or severe liver disease
 WARNINGS AND PRECAUTIONS
- A yellowish tinge of the skin or sclera may indicate accumulation due to impaired renal excretion and the need to discontinue therapy.
- The decline in renal function associated with advanced age should be kept in mind.
- Phenazopyridine produces an orange to red color in the urine and feces, and may cause staining. Phenazopyridine may cause discoloration of body fluids and staining of contact lenses has been reportedd.
The medical literature to date suggests that no significant interactions have been reported.
 PREGNANCY AND LACTATION
- Pregnancy Category B (US). Phenazopyridine should be used during pregnancy only if clearly needed.
- Nursing Mothers: No information is available on the appearance of Phenazopyridine or its metabolites in human milk. Because many drugs are excreted in human milk, a decision should be made to discontinue nursing or to discontinue the drug, taking into account the importance of drug therapy to the mother.
 SIDE EFFECTS
- CNS: headache.
- Gastrointestinal: nausea, vomiting and diarrhea.
- Dermatologic and Hypersensitivity: rash, pruritus, discoloration, anaphylactoid-like reaction and hypersensitivity hepatitis.
- Hematologic: methemoglobinemia, hemolytic anemia, potential hemolytic agent in G-6-PD deficiency.
- Other: visual disturbances, renal and hepatic toxicity usually associated with overdose, renal calculi, jaundice, staining contact lens, discolouration of urine and other body fluids.